AQUA004 - ACSS Sanitet

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Alg-1007

proof-of-concept study in humans, and is currently being evaluated in a second and larger ex-U.S. Phase 2 study. ALG-1007 for topical use in dry eye disease demonstrated an improvement in both signs and symptoms of DED Allegro has initiated a second larger exploratory ex-US DED study looking at higher doses in a vehicle-controlled study Safety and efficacy of ALG-1007 topical ophthalmic solution – A synthetic peptide that regulates inflammation, in patients with dry eye disease: An exploratory Phase I, open-label, single-center clinical study Risuteganib is an integrin-regulating therapy that reduces mitochondrial dysfunction involved in intermediate dry AMD and DME. By targeting multiple pathways, risuteganib helps reduce the cellular burden of oxidative stress and restores retinal homeostasis. 1. a Animal retinopathy of prematurity [ROP] models.

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The topical agent is under evaluation in a phase 2 study outside of the U.S. and is the company’s first exploratory drug not in the retina space. 2019-05-10 · SAN DIEGO — At the American Society of Cataract and Refractive Surgery meeting, Eric D. Donnenfeld, MD, discusses ALG-1007, in development from Allegro Ophthalmics, a new small peptide anti Bausch Health anticipates that Allegro’s ophthalmic assets will complement its portfolio of AMD products. Bausch Health CEO and chairman Joseph Papa said: “If approved, risuteganib may be the first treatment indicated to help reverse vision loss due to dry AMD and would address a significant unmet medical need affecting millions of people globally.” 2019-05-17 · ALG-1007 also was well tolerated, with no drug-related adverse events. The trial included 40 eyes of 21 patients diagnosed with dry eye for at least 6 months.

04.30.19. Allegro to Present Results of Its ALG-1007 Ex-US Trial for Dry Eye Disease at ASCRS.
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proof-of-concept clinical trial in which it showed a dose response curve and that it was generally well-tolerated. ALG-1007 (Allegro Ophthalmics, San Juan Capistrano, CA, USA) is a topical application of risuteganib, a small peptide integrin regulator that modulates multiple integrin subunits, including integrin αM and β2, the subunits involved in complement 3 inflammatory pathways. [ 11, 12] Gene expression studies have demonstrated reduced gene level of integrin αM and β2 submits in mice retina treated with risuteganib.